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Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide.1 High systolic blood pressure (SBP) remains one of the top risk factors for CVD burden globally.2 Despite being a modifiable risk factor, hypertension (HTN) remains largely undiagnosed and untreated due to inadequate screening, poor awareness and lack of treatment adherence.3 Globally, HTN is undiagnosed in about 46% […]

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22 Results Found for “phase mapping”

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Ventricular fibrillation (VF) is characterized by rapid (>300 beats a per minute), irregular electrical activation with variable electrocardiographic waveforms that prevents coordinated myocardial contraction, resulting in immediate loss of cardiac output.1 It most commonly occurs in the context of coronary ...

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Transthyretin amyloid cardiomyopathy (ATTR-CM) is an inexorably progressive and ultimately fatal cardiomyopathy characterized by the deposition of misfolded transthyretin (TTR) in the form of amyloid fibrils within the myocardium.1 Transthyretin amyloid (ATTR) fibrils are insoluble protease-resistant beta-pleated sheets that are ...

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Infiltrative cardiomyopathies are a diverse group of cardiac diseases caused by the deposition of abnormal substances within the myocardium and include diseases, such as Fabry disease, sarcoidosis and less common genetic diseases, such as Friedreich’s ataxia and Danon disease.1 ...

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The systemic amyloidoses are a group of heterogenous diseases, which are characterized by the deposition of insoluble amyloid fibrils within the extracellular matrix of multiple organs throughout the body. Amyloid fibrils are formed from the misfolding of amyloid precursor proteins (...

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Jana P Lovell, Daniela Čiháková, Nisha A Gilotra

Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2), has been associated with several cardiovascular disease manifestations, including acute coronary syndromes, arrhythmias, heart failure, thromboembolic complications and myocardial injury.1 Myocardial injury, defined as elevation in serum cardiac troponin ...

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Melanie Dani, Dimitrios Panagopoulos, Andreas Dirksen

Vasovagal syncope is common, and while it is usually associated with a benign prognosis, it results in significant physical and psychological morbidity for affected individuals. Despite comprehensive understanding of the underlying pathophysiology, there have been few definitive therapeutic advances until ...

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Paroxysmal supraventricular tachycardia (PSVT) defines a group of cardiac arrhythmias where the underlying mechanism is dependent upon structures at or above the level of the atrioventricular node. The recent PRE-EMPT study retrospectively evaluated health records of over 4.2 million people in ...

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Johanna Tonko (Presenting Author) – University College London, London, UK; MT Tourni – Columbia University, New York City, NY, USA; EK Konofagou – Columbia University, New York City, NY, USA; PL Lambiase – University College London, London, UK

Introduction: The restriction of activation mapping to the ventricular surface of contemporary mapping systems often leads to failure to correctly identify the true site of origin (SOO) of intramural and/or sub-epicardial Vas and lower procedural success. Electromechanical wave imaging (...

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CE Lopez-Barrera (Presenting Author) - Queen Mary University of London, London, UK; C Roney - Queen Mary University of London, London, UK; CR Santillan-Rodriguez - Centro de Investigacion en Materiales Avanzados, Chihuahua, Mexico

Background: The spatial resolution of a mapping catheter is determined by factors such as the quantity of electrodes, their inter-electrode spacing, and the various configurations in which they are utilized. These factors impact the interpretation of wavefront dynamics during cardiac ...

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Chiara Scrocco, Bode Ensam, Elijah R Behr

A survivor of cardiac arrest due to ventricular fibrillation (VF), without a cardiac, respiratory, metabolic, or toxicological explanation, is diagnosed with idiopathic VF.1 Idiopathic VF is estimated to account for approximately 5–7% of all out-of-hospital cardiac arrest cases.2,3 Furthermore, the Cardiac ...

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  Atrial fibrillation (AF) is one of the most frequent arrhythmias worldwide, and, despite progress in the management of patients with AF, remains one of the major causes of stroke, heart failure, sudden death, and cardiovascular morbidity.1 The incidence and ...

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With the introduction of invasive and noninvasive phase mapping in humans, visualisation of rotor activity during atrial fibrillation has emerged as a new concept.1–3 However, phase maps rendered during human atrial fibrillation using noninvasive information from body-surface electrocardiograms (ECGs) versus ...

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Dear Colleagues, Welcome to the spring 2018 edition of the European Journal of Arrhythmia & Electrophysiology. I hope that you will enjoy reading the selection of articles in this issue, which all offer insights into a range of pertinent topics in ...

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Premature ventricular contractions (PVCs) arising from the Purkinje network are rare causes of idiopathic ventricular fibrillation (IVF).1–4Van Herendael and colleagues recently highlighted the importance of triggers from the papillary muscles (PM) and the left ventricular outflow tract in the ...

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Of the three leads placed during cardiac resynchronisation therapy (CRT), the left ventricular (LV) lead is the most important and also needs to be placed precisely in the region that is activated last – hence it becomes the most difficult leads ...

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GR Raffaele (Presenting Author) – Faculty of Life Sciences and Medicine, King’s College London, London; CHR Roney – School of Biomedical Engineering and Imaging Sciences, King’s College London; School of Engineering and Materials Science, Queen Mary University of London, London; IK Kotadia – School of Biomedical Engineering and Imaging Sciences, King’s College London, London; JAS-L Solis-Lemus – School of Biomedical Engineering and Imaging Sciences, King’s College London, London; IS Sim – School of Biomedical Engineering and Imaging Sciences, King’s College London, London; JW Whitaker – School of Biomedical Engineering and Imaging Sciences, King’s College London; The Department of Internal Medicine, Cardiovascular Division, Brigham and Women’s Hospital, Boston; OR Razeghi – School of Biomedical Engineering and Imaging Sciences, King’s College London, London; MO O’Neill – School of Biomedical Engineering and Imaging Sciences, King’s College London, London; SEW Williams – School of Biomedical Engineering and Imaging Sciences, King’s College London, London; Centre for Cardiovascular Science, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh; SMN Narayan – Department of Medicine and Cardiovascular Institute, Stanford University, Palo Alto; SAN Niederer – School of Biomedical Engineering and Imaging Sciences, King’s College London, London

Introduction: Atrial fibrillation (AF) is the most common cardiac arrhythmia, affecting over 1.4 million people in the UK alone, and is associated with an increased risk of cardiovascular diseases, stroke and death. AF is often treated by catheter ablation therapy, which ...

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MTB Pope (Presenting Author) - Oxford University Hospitals NHS Foundation Trust, Oxford; P Kuklik - Asklepios Clinic St. Georg, Hamburg; A Banerjee - University of Oxford, Oxford; A Briosa e Gala - Oxford University Hospitals NHS Foundation Trust, Oxford; M Leo - Oxford University Hospitals NHS Foundation Trust, Oxford; M Mahmoudi - University of Southampton, Southampton; J Paisey - Southampton University Hospitals NHS Foundation Trust, Southampton; TR Betts- Oxford University Hospitals NHS Foundation Trust, Oxford

Introduction: Characterising patient-specific atrial fibrillation (AF) phenotype may lead to individualised approaches and improve ablation outcomes. Our novel mapping approach based on signal recurrence plots has not previously been applied to whole chamber, bi-atrial recording of AF. Methods: Simultaneous bi-atrial 30...

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MTB Pope (Presenting Author) - Oxford University Hospitals NHS Foundation Trust, Oxford, UK; P Kuklik - Department of Cardiology, Electrophysiology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany; P John - University of Southampton, Southampton, UK; M Mahmoudi - University of Southampton, Southampton, UK; R Betts - Oxford University Hospitals NHS Foundation Trust, Oxford, UK

Background: Adenosine is known to shorten atrial action potential duration and refractoriness, promoting atrial fibrillation (AF). It may also be used during non-contact mapping of atrial propagation to reduce the impact of far-field ventricular signals. However, the functional effect of ...

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