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Cardiovascular diseases are the most common cause of mortality and morbidity in adults worldwide.1 Coronary angiography (CAG) is the gold standard method for evaluating atherosclerotic coronary artery disease (CAD).2 It is conventionally performed via the trans-femoral (TF) route. Recently, however, the trans-radial (TR) route has become the preferred way.3 The TR route offers better procedure comfort, shorter hospitalization […]

Filipe Moura, ESC 2022: A post-hoc analysis of the DECLARE-TIMI 58 and DAPA-CKD trials of dapagliflozin in patients with type 2 diabetes

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Published Online: Sep 6th 2022

Combining data from the DECLARE and DAPA-CKD trials enables the effect of dapagliflozin to be examined across a spectrum of baseline kidney function. In this touchCARDIO interview, we speak with Dr Filipe Moura (Brigham and Women’s Hospital, Harvard Medical School, Boston, USA) to discuss the post-hoc analysis of the DECLARE and DAPA-CKD data and the significance for clinical practice.

The abstract entitled ‘Effects of dapagliflozin on cardiovascular and kidney events by baseline eGFR and UACR in patients with type 2 diabetes mellitus: A patient-level pooled analysis of DECLARE-TIMI 58 and DAPA-CKD trials’ was presented at the European Society of Cardiology (ESC) Congress 2022, 26 – 29 August 2022.

Questions:

  1. What was the purpose of the post-hoc analysis of the DECLARE and DAPA-CKD data? (0:21)
  2. What subgroups were evaluated in this study? (1:28)
  3. What were the findings in the different baseline eGFR and urinary albumin: creatinine ratio groups? (2:59)
  4. What is the significance of these findings for clinical practice? (5:11)

Disclosures: Filipe Moura has nothing to disclose in relation to this video interview.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Danielle Crosby.

Filmed as a highlight of ESC 2022

Access more content on Cardiovascular Risk here

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