{"id":431,"date":"2018-07-30T10:11:18","date_gmt":"2018-07-30T10:11:18","guid":{"rendered":"https:\/\/touchcardio.com\/2018\/07\/30\/coronary-artery-disease-left-ventricular-hypertrophy-and-diastolic-dysfunction-are-associated-with-stroke-in-patients-affected-by-persistent-non-valvular-atrial-fibrillation-a-case-control-study\/"},"modified":"2019-10-15T16:32:15","modified_gmt":"2019-10-15T15:32:15","slug":"coronary-artery-disease-left-ventricular-hypertrophy-and-diastolic-dysfunction-are-associated-with-stroke-in-patients-affected-by-persistent-non-valvular-atrial-fibrillation-a-case-control-study","status":"publish","type":"post","link":"https:\/\/touchcardio.com\/arrhythmia\/journal-articles\/coronary-artery-disease-left-ventricular-hypertrophy-and-diastolic-dysfunction-are-associated-with-stroke-in-patients-affected-by-persistent-non-valvular-atrial-fibrillation-a-case-control-study\/","title":{"rendered":"Coronary artery disease, left ventricular hypertrophy and diastolic dysfunction are associated with stroke in patients affected by persistent non-valvular atrial fibrillation: a case-control study"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":53489,"featured_media":4196,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","rank_math_lock_modified_date":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-431","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","vocabulary_1-arrhythmia","vocabulary_1-atherosclerosis","vocabulary_1-atrial-fibrillation"],"acf":{"wpcf-article_introduction":"","wpcf-article_abstract":"Persistent non-valvular atrial fibrillation\r\n(NVAF) is associated with an increased risk\r\nof cardiovascular events such as stroke, and\r\nits rate is expected to rise because of the\r\nageing population. The absolute rate of\r\nstroke depends on age and comorbidity. Risk\r\nstratification for stroke in patients with\r\nNVAF derives from populations enrolled in\r\nrandomized clinical trials. However, participants\r\nin clinical trials are often not representative\r\nof the general population. Many stroke\r\nrisk stratification scores have been used, but\r\nthey do not include transthoracic echocardiogram\r\n(TTE), pulsate wave Doppler (PWD)\r\nand tissue Doppler imaging (TDI), simple\r\nand non- invasive diagnostic tools. The role\r\nof TTE, PWD and TDI findings has not been\r\npreviously determined. Our study goal was to\r\ndetermine the association between TTE and\r\nPWD findings and stroke prevalence in a population\r\nof NVAF prone outpatients.\r\nPatients were divided into two groups: P\r\nfor stroke prone and F for stroke free. There\r\nwere no statistically significant differences between the two groups concerning cardiovascular\r\nrisk factors, age (p=0.2), sex\r\n(p=0.2), smoking (p=0.3), diabetes (p=0.1)\r\nand hypercholesterolemia (p=0.2); hypertension\r\nwas statistically significant (p<0.001).\r\nThere were statistically significant differences\r\nconcerning coronary artery disease,\r\nprevious acute myocardial infarction (AMI)\r\n(p<0.05) and non- AMI coronaropathy\r\n(p<0.04), a higher rate being in the P group.\r\nConcerning echo-Doppler findings, a higher\r\nstatistically significant rate of left ventricular\r\nhypertrophy (LVH) (p<0.05) and left ventricular\r\ndiastolic dysfunction (p<0.001) was\r\nfound in the P group and dilated left atrium\r\n(p<0.04) in the F group, the difference was\r\nnot significant for mitral regurgitation\r\n(p=0.7). Stroke prone NVAF patients have a\r\nhigher rate of hypertension, coronary artery\r\ndisease, with and without AMI, LVH and left\r\nventricular diastolic dysfunction, but not left\r\natrial dilatation. M-B mode echocardiography\r\nand PWD examination help to identify highrisk\r\nstroke patients among NVAF subjects;\r\ntherefore, they may help in the selection of\r\nappropriate therapy for each patient.","wpcf-article_keywords":"Atrial fibrillation, stroke, hypertension, coronary artery disease, left ventricular hypertrophy, left atrial dilatation, echocardiography.","wpcf-article_citation_override":"Heart International<\/i> 2009;4(1):e2","wpcf-compliance-with-ethics":"","wpcf-article_disclosure":"","wpcf-review_process":"","wpcf-authorship":"","wpcf-article_correspondence":"Pasquale Palmiero, Via Francia 47, 72100 Brindisi, Italy E-mail: pasqualepalmiero@iciscu.org","wpcf-article_support":"","wpcf-open_access":"","wpcf-article_pdf":"https:\/\/touchcardio.com\/wp-content\/uploads\/sites\/4\/2018\/07\/private_articles_22469_pdf_HEI_2009_4_1-10-4081_hi-2009-e2.pdf","wpcf-article_pdf-gated":true,"wpcf-article_doi":"https:\/\/doi.org\/10.4081\/hi.2009.e2","wpcf-old_nid":"","wpcf-article_image":"https:\/\/touchcardio.com\/wp-content\/uploads\/sites\/4\/2018\/08\/Thumbnails_heart.png","wpcf-editor_choice":false,"wpcf-old_author_ids":"","wpcf-article_references":"","wpcf-article_received_date":"2008-01-09T00:00:00","wpcf-article_accepted_date":"2008-03-02T00:00:00","wpcf-article_published_online":"2009-12-01T00:00:00","wpcf-podcast":"","wpcf-ogg":"","wpcf-article_end_page":"","wpcf-article_start_page":"","wpcf-acknowledgements":"The authors thank the nurse,\r\nMrs. Grazia Quaranta, for her support in management\r\nof patients enrolled in this study.","wpcf-errata_pdf":"","wpcf-article_flipper_image":"https:\/\/touchcardio.com\/wp-content\/uploads\/sites\/4\/2018\/08\/Flipper-Files14.jpg","wpcf-corrected_online":null,"wpcf-supplementary_information":"","wpcf-article_highlight_pdf":"","data_availability":"","digital_features":""},"_links":{"self":[{"href":"https:\/\/touchcardio.com\/wp-json\/wp\/v2\/posts\/431","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/touchcardio.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/touchcardio.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/touchcardio.com\/wp-json\/wp\/v2\/users\/53489"}],"replies":[{"embeddable":true,"href":"https:\/\/touchcardio.com\/wp-json\/wp\/v2\/comments?post=431"}],"version-history":[{"count":1,"href":"https:\/\/touchcardio.com\/wp-json\/wp\/v2\/posts\/431\/revisions"}],"predecessor-version":[{"id":4198,"href":"https:\/\/touchcardio.com\/wp-json\/wp\/v2\/posts\/431\/revisions\/4198"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/touchcardio.com\/wp-json\/wp\/v2\/media\/4196"}],"wp:attachment":[{"href":"https:\/\/touchcardio.com\/wp-json\/wp\/v2\/media?parent=431"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/touchcardio.com\/wp-json\/wp\/v2\/categories?post=431"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/touchcardio.com\/wp-json\/wp\/v2\/tags?post=431"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}