{"id":753,"date":"2018-08-20T11:52:23","date_gmt":"2018-08-20T11:52:23","guid":{"rendered":"https:\/\/touchcardio.com\/2018\/08\/20\/combined-administration-of-the-gpvi-fc-fusion-protein-revacept-with-low-dose-thrombolysis-in-the-treatment-of-stroke\/"},"modified":"2018-08-20T11:52:23","modified_gmt":"2018-08-20T11:52:23","slug":"combined-administration-of-the-gpvi-fc-fusion-protein-revacept-with-low-dose-thrombolysis-in-the-treatment-of-stroke","status":"publish","type":"post","link":"https:\/\/touchcardio.com\/thrombosis\/journal-articles\/combined-administration-of-the-gpvi-fc-fusion-protein-revacept-with-low-dose-thrombolysis-in-the-treatment-of-stroke\/","title":{"rendered":"Combined administration of the GPVI-Fc fusion protein Revacept with low-dose thrombolysis in the treatment of stroke"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":53489,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","rank_math_lock_modified_date":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-753","post","type-post","status-publish","format-standard","hentry","category-uncategorized","vocabulary_1-thrombosis"],"acf":{"wpcf-article_introduction":"","wpcf-article_abstract":"Background.<\/b> Thrombolytic therapy with recombinant tissue plasminogen activator (rtPA) remains the only approved\r\nmedication for acute ischemic stroke, but incurs significant bleeding risks. Therefore, approaches to\r\ncombine lower doses of thrombolytic therapy with other effective drugs aim at improving efficacy and reducing\r\nbleeding rates. We examined the safety and therapeutic effects of various dosings of rtPA, either alone or combined\r\nwith glycoprotein VI-Fc fusion protein (GPVI-Fc, Revacept) on experimental stroke in mice.\r\nMethods and results.<\/b> The effect of filament-induced intracerebral thrombus formation and embolization was\r\ninvestigated after a one-hour occlusion of the middle cerebral artery.\r\nIn accordance with previous studies, treatment with 10 mg\/kg rtPA significantly improved functional outcome, cerebral\r\ninfarct size and edema, but also resulted in markedly increased intracranial bleeding volumes. In contrast, low\r\ndoses of rtPA (0.1 or 0.35 mg\/kg body weight) did not change outcome parameters. However, addition of 1 mg\/kg\r\nRevacept to 0.35 mg\/kg rtPA led to improved reperfusion compared to rtPA alone. Moreover, these combined treatments\r\nresulted in improved grip strength, compared to the respective dose of rtPA alone. Infarct-surrounding edema\r\nimproved after combined treatments, but not after respective single rtPA dosings. Intracranial bleeding volumes were\r\nbelow controls after all low-dose rtPA therapies, given either alone or combined with Revacept.\r\nConclusions.<\/b> In contrast to using the equally effective full dose of rtPA, intracranial bleeding was not increased by\r\nlow-dose rtPA combined with Revacept. Therefore, addition of Revacept to low-dose rtPA does not incur safety\r\nrisks, but improves efficacy of treatment.","wpcf-article_keywords":"Glycoprotein VI, Middle cerebral artery occlusion, Platelet aggregation, Stroke","wpcf-article_citation_override":"Heart International<\/i>. 2016;11(1):e10-e16","wpcf-compliance-with-ethics":"","wpcf-article_disclosure":"Financial support: This study was supported by a grant from the Bavarian\r\nResearch Foundation (Bayerische Forschungsstiftung), grant\r\n# 1145-14.","wpcf-review_process":"","wpcf-authorship":"","wpcf-article_correspondence":"Martin Ungerer AdvanceCOR GmbH \u2013 Procorde Fraunhofer Str. 9a 82152 Martinsried, Germany ungerer@advancecor.com; Meinrad Gawaz University of T\u00fcbingen Otfried-M\u00fcller-Str. 10 72076 T\u00fcbingen, Germany meinrad.gawaz@med.uni-tuebingen.de","wpcf-article_support":"","wpcf-open_access":"","wpcf-article_pdf":"https:\/\/touchcardio.com\/wp-content\/uploads\/sites\/4\/2018\/08\/private_articles_22925_pdf_HEI_2016_11_1-5000229.pdf","wpcf-article_pdf-gated":true,"wpcf-article_doi":"https:\/\/doi.org\/10.5301\/heartint.5000229","wpcf-old_nid":"","wpcf-article_image":"https:\/\/touchcardio.com\/wp-content\/uploads\/sites\/4\/2018\/08\/Thumbnails_cardio3_4.png","wpcf-editor_choice":true,"wpcf-old_author_ids":"","wpcf-article_references":"","wpcf-article_received_date":null,"wpcf-article_accepted_date":"2016-03-31T00:00:00","wpcf-article_published_online":"2016-04-25T00:00:00","wpcf-podcast":"","wpcf-ogg":"","wpcf-article_end_page":"","wpcf-article_start_page":"","wpcf-acknowledgements":"We acknowledge the excellent technical assistance of Isabel Fodor.","wpcf-errata_pdf":"","wpcf-article_flipper_image":"https:\/\/touchcardio.com\/wp-content\/uploads\/sites\/4\/2018\/08\/Flipper-Files15_4.jpg","wpcf-corrected_online":null,"wpcf-supplementary_information":"","wpcf-article_highlight_pdf":"","data_availability":"","digital_features":""},"_links":{"self":[{"href":"https:\/\/touchcardio.com\/wp-json\/wp\/v2\/posts\/753","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/touchcardio.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/touchcardio.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/touchcardio.com\/wp-json\/wp\/v2\/users\/53489"}],"replies":[{"embeddable":true,"href":"https:\/\/touchcardio.com\/wp-json\/wp\/v2\/comments?post=753"}],"version-history":[{"count":0,"href":"https:\/\/touchcardio.com\/wp-json\/wp\/v2\/posts\/753\/revisions"}],"wp:attachment":[{"href":"https:\/\/touchcardio.com\/wp-json\/wp\/v2\/media?parent=753"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/touchcardio.com\/wp-json\/wp\/v2\/categories?post=753"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/touchcardio.com\/wp-json\/wp\/v2\/tags?post=753"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}