The focus in antioxidant research is on
enzyme derivative investigations. Extracellular
superoxide dismutase (EC-SOD) is of particular
interest, as it demonstrates in vivo the
protective action against development of atherosclerosis,
hypertension, heart failure, diabetes
mellitus. The reliable association of
coronary artery disease with decreased level of
heparin-released EC-SOD was established in
clinical research. To create a base for and to
develop antioxidant therapy, various SOD
isozymes, catalase (CAT), methods of gene
therapy, and combined applications of
enzymes are used. Covalent bienzyme SODCHS-
CAT conjugate (CHS, chondroitin sulphate)
showed high efficacy and safety as the
drug candidate. There is an evident trend to
use the components of glycocalyx and extracellular
matrix for target delivery of medical
substances. Development of new enzyme
antioxidants for therapeutic application is
closely connected with progress in medical
biotechnology, pharmaceutical industry, and
bioeconomy.
Reactive oxygen species, enzyme antioxidants, oxidative stress, cardiovascular diseases, vascular wall injury, endothelial glycocalyx, extracellular superoxide dismutase, catalase, novel bienzyme superoxide dismutase – chondroitin sulphate – catalase conj
Alexander V. Maksimenko, Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, 3- rd Cherepkovskaya Street 15A, 121 552 Moscow, Russia Tel. +7.495.414.60.25 – Fax: +7.499.726.31.16. E-mail: alexmak@cardio.ru
The authors sincerely thank
and highly appreciate the support of research and
efficient discussions with professors EI Chazov,
VN Smirnov, AM Egorov, EV Arzamastcev, VI
Kapelko, VZ Lankin, EK Ruuge, AK Tichaze. This
work was performed thanks to the support of the
grants of Russian Foundation for Basic Research
07-04-12057-ofi, 09-08-00023, Rosmedtechnologies
Agency and Roszdravsozrazvitija Ministry of
Russian Federation.
2011-06-16
Trending Topic
Cardiovascular diseases are the most common cause of mortality and morbidity in adults worldwide.1Â Coronary angiography (CAG) is the gold standard method for evaluating atherosclerotic coronary artery disease (CAD).2Â It is conventionally performed via the trans-femoral (TF) route. Recently, however, the trans-radial (TR) route has become the preferred way.3Â The TR route offers better procedure comfort, shorter hospitalization […]
We are sorry to announce the death of one of our valued editorial board members, Dr Richard Heuser (November 17, 1950–May 23, 2024). Richard R Heuser, MD, FACC, FACP, FESC, MSCAI, was an internationally recognized cardiologist, inventor, educator and author, and was a ...
Welcome to the summer issue of Heart International. We are excited to present a collection of insightful articles that delve into various aspects of cardiovascular health and related interventions. This issue encompasses a wide array of topics, from novel treatment ...
Clinically relevant tricuspid regurgitation (TR) is a common disorder, affecting approximately 4% of people 75 years of age or older.1Â If left untreated, severe TR results in volume overload and right ventricular remodelling. This eventually leads to symptomatic right-sided heart failure, along ...
In this issue of Heart International, we are delighted to present a collection of insightful articles that encompass a wide spectrum of topics within the field of cardiovascular medicine. As we navigate the landscape of cardiovascular disease, heart failure, preventative ...
For decades, right ventricular pacing (RVP) has been the leading pacing technique and has been proven to be effective in treating patients with symptomatic bradycardia. However, dyssynchrony caused by non-physiological ventricular activation results in pacing-induced cardiomyopathy occurs in approximately 15% of ...
Welcome to the latest issue of Heart International. This edition includes a range of articles on topics showcasing the latest advances in our understanding and treatment of cardiovascular disease. We begin with focus on the hereditary cardiac disorder, hypertrophic cardiomyopathy, ...
A significant proportion of patients with atrial fibrillation (AF) who have a high stroke risk are currently being treated with oral anticoagulation (OAC), including direct oral anticoagulants (DOACs) and vitamin K inhibitors (VKAs).1Â It is well known that the increased ...
The American Diabetes Association (ADA) defines prediabetes as glycated haemoglobin (HbA1c) 5.7–6.4% or fasting plasma glucose (FPG) 100–125 mg/dL or 5.6–6.9 mmol/L.1 Patients with prediabetes have up to a 70% chance of developing diabetes and a two-fold higher risk of cardiovascular ...
Mitral valve (MV) disease includes either mitral regurgitation or mitral stenosis or both. The incidence and prevalence of valvular heart disease is increasing with the increasing population age. Degenerative MV disease poses a global burden with a prevalence of 18.1 million ...
Welcome to the latest issue of Heart International. Cardiovascular science continues to evolve at an impressive rate, and the range of articles presented here highlights cutting-edge technology and innovation within cardiology. We begin with a commentary by Divaka Perera on ...
Welcome to the latest issue of Heart International. We are delighted to bring you another excellent issue, full of the varied and expert articles that you can expect from our authors. We begin with some exciting news. We are delighted ...
Tricuspid regurgitation (TR) is a complex disease with several independent causes. Consequently, outcomes and response to therapy vary widely. Severe or progressive TR often results in gradual right ventricular (RV) failure and is associated with poor long-term outcomes.1Â Most cases ...
Earn and track your CME credits on the go, save articles for later, and follow the latest congress coverage.
Register for free to hear about the latest expert-led education, peer-reviewed articles, conference highlights, and innovative CME activities.
Or use a Social Account.
Explore the latest in medical education and stay current in your field. Create a free account to track your learning.