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Mechanistic interpretations of sustained ventricular fibrillation: The role of mapping methodology, model and time

Johanna B Tonko, Vineesh Kappadan, Ahmed El-Medany

Ventricular fibrillation (VF) is characterized by rapid (>300 beats a per minute), irregular electrical activation with variable electrocardiographic waveforms that prevents coordinated myocardial contraction, resulting in immediate loss of cardiac output.1 It most commonly occurs in the context of coronary artery disease.2,3 Resuscitation efforts are critically time-dependent: with each minute of untreated VF, the survival rate declines […]

Heart International. 2026;20(1):5-19

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