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The foramen ovale, an obligatory channel, allows placental oxygenated blood to directly reach the fetal arterial circulation and remains patent in 25% of the adult population.1 Patency provides a potential gateway for venous emboli to reach the arterial circulation, potentially resulting in systemic embolus or stroke (now termed ‘patent foramen ovale [PFO]-associated stroke’).2 Preventive strategies for recurrent […]

Obesity

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Physician burnout is at a critical point. In this episode, Nicky speaks with Dr Alfred Atanda about why so many physicians are burning out and what can be done to change the trend. From personal experience to system-wide solutions, Dr Atanda shares valuable insights on improving physician well-being and building a more effective healthcare culture.

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What if your medical degree could launch more than a clinical career? In this candid and compelling read, Dr Jon Edelson shares his lessons for early-career clinicians ready to think beyond the bedside and explore the business of medicine.

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In this episode, we explore the future of continuing medical education (CME) with the team behind touchIME. Hannah Fisher and Matthew Goodwin share insights into global and US trends, the importance of patient inclusivity and how educational outcomes are evolving to better measure the direct impact of learning on clinical practice and patient care.

45 mins
CE/CME accredited
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Prof. Carel le Roux, Dr Susan Pedersen, Dr Donna Ryan

The potential future role of GLP-1–based combinations in the management of obesity with or without diabetes.

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Glucagon-like peptide 1 (GLP-1) receptor agonists piqued our interest when Marso et al. demonstrated that liraglutide significantly reduced cardiovascular events (CVEs) in persons with type 2 diabetes mellitus (T2DM) who were at a high cardiovascular (CV) risk compared with placebo in ...

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With the global increase in life expectancy, the proportion of elderly people in the community is expected to increase gradually. This is referred to as the 'Coming of the Gray Dawn' or the 'Gray Wave', and highlights the need for ...

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M Ardissino (Presenting Author) - Imperial College London, London; RK Reddy - Imperial College London, London; KHK Patel - Imperial College London, London; DK Ryan - St George’s University Hospitals NHS Foundation Trust, London; D Gill - Imperial College London, London; FS Ng - Imperial College London, London

Aims: The association between obstructive sleep apnoea (OSA) and atrial fibrillation (AF) is yet to be fully delineated. Although several observational studies have suggested an independent association between OSA and AF, subsequent randomised controlled trials have failed to demonstrate any ...

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K Nyamakope (Presenting Author) - NHLI Imperial College London, London; KHK Patel - NHLI Imperial College London, London; X Li - NHLI Imperial College London, London; J Stoks - Maastricht University, Maastricht; R Davidson - NHLI Imperial College London, London; B Statton - MRC London Institute of Medical Sciences, London; M Brezitski - MRC London Institute of Medical Sciences, London; A Berry - MRC London Institute of Medical Sciences, London; H Bergman - MRC London Institute of Medical Sciences, London; M Orini - University College London, London; S Purkayastha - NHLI Imperial College London, London; P Lambiase - University College London, London; NS Peters - NHLI Imperial College London, London; D O’Regan - MRC London Institute of Medical Sciences, London; M Cluitmans - Maastricht University, Maastricht; FS Ng - NHLI Imperial College London, London

Background: Obesity is associated with an increased risk of ventricular arrhythmias and sudden cardiac death. Although the 12-lead electrocardiogram (ECG) may detect repolarisation abnormalities, it lacks the spatial resolution for detailed characterisation of the proarrhythmic substrate associated with obesity. We ...

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