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Doctor holding glowing holographic human anatomical heart. Medical illustration, heart diseases, heart health
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Native valve infective endocarditis (IE) is rare, with an incidence of 3–7 cases per 100,000 person-years.1,2 Cardiac structural complications from local infection extension include valvular destruction, peri-annular abscess and fistula formation. Left ventricular pseudoaneurysm (LVP) from IE is exceedingly rare, occurring in <1% of cases, and is associated with high morbidity and mortality. Diagnosis is challenging due to nonspecific symptoms […]

ESC

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Large language models, wearables and mobile health technologies are increasingly being explored across cardiovascular research and clinical care. At ESC Congress 2026, Dr Jazmin Aguado-Sierra discussed where these tools could add value, and where questions around reliability remain.

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Dr Jazmin Aguado-Sierra discusses how computational models and digital twins are helping researchers understand different heart failure phenotypes, and how artificial intelligence can accelerate analysis and support more personalized approaches.

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Coverage from: ESC Highlights
Jens Cosedis Nielsen

Prof. Jens Cosedis Nielsen discusses the DANISH-CRT trial, why targeted electrical mapping did not improve outcomes, and the questions that remain around the future of cardiac resynchronization therapy.

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Coverage from: ESC Highlights
James Januzzi

Phase IIb LUMINARA data presented at ESC Congress 2026 suggest that AZD5462 may improve cardiac remodeling and hemodynamics across different heart failure phenotypes, with the lowest dose producing the strongest remodeling signal in HFrEF.

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Coverage from: ESC Highlights
Jonathan Kalman

Prof. Jonathan Kalman discusses the rapid uptake of pulsed field ablation, its potential advantages over thermal ablation, and how the role of AF ablation may continue to expand.

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Coverage from: ESC Highlights
Adrian Voors

Prof. Adriaan Voors discusses the evolving role of GLP-1 receptor agonists in heart failure, the importance of patient selection and monitoring, and how emerging evidence and new guidelines could influence clinical practice.

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Coverage from: ESC Highlights
Bjarne Nes

Dr Bjarne Nes discusses findings from the NEXAF trial, which showed that a one-year exercise program reduced atrial fibrillation burden in patients with non-permanent AF.

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AMUNDSEN showed that immediate initiation of evolocumab after myocardial infarction substantially increased LDL-C goal achievement, but did not significantly reduce death or cardiovascular hospitalization at 1 year. Starting evolocumab immediately after myocardial infarction (MI) more than doubled the proportion of patients ...

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Coverage from: ESC Highlights
George Stergiou

Prof. George Stergiou discusses wearable, cuffless and screening technologies for blood pressure measurement, where they may add value, and why accuracy remains critical for clinical decision-making.

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Phase III SHASTA-3 and SHASTA-4 results showed substantial and sustained triglyceride reductions with plozasiran, alongside fewer acute pancreatitis events.

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PRAGUE-26 found that catheter-directed thrombolysis substantially reduced short-term clinical deterioration compared with anticoagulation alone in patients with intermediate–high-risk pulmonary embolism.

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Phase III ACACIA-HCM results show significant improvements in symptoms and functional capacity with aficamten in patients with symptomatic non-obstructive hypertrophic cardiomyopathy.

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The first dedicated ESC Guidelines on the management of cardiovascular disease and chronic kidney disease recommend kidney function and urine albumin testing in all patients with cardiovascular disease, with an emphasis on identifying CKD early and initiating effective treatment without delay.

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Eplontersen did not significantly reduce cardiovascular mortality and recurrent cardiovascular events compared with placebo in the overall CARDIO-TTRansform population, according to late-breaking results presented at ESC Congress 2026 in Munich, Germany.

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New 2026 ESC Guidelines for the management of heart failure introduce major changes to the classification of heart failure and its treatment, with an increased focus on prevention, earlier intervention and timely referral of patients with advanced disease.

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Direct oral anticoagulant (DOAC) therapy reduced adverse clinical events compared with no anticoagulation in patients with atrial fibrillation (AF) at intermediate risk of stroke, according to results from the SINGLE-AF trial presented during a Hot Line session at ESC Congress 2026.1

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Coverage from: ESC Highlights

New heart failure guidelines, practice-changing Hot Line data, artificial intelligence and new evidence in atrial fibrillation and cardiac amyloidosis are among the highlights to look out for on the opening day of ESC Congress 2026.

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Join us to learn more about the latest data, expert insights and key clinical takeaways from across the congress, and what they could mean for your clinical practice.
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