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Cardiovascular diseases are the most common cause of mortality and morbidity in adults worldwide.1 Coronary angiography (CAG) is the gold standard method for evaluating atherosclerotic coronary artery disease (CAD).2 It is conventionally performed via the trans-femoral (TF) route. Recently, however, the trans-radial (TR) route has become the preferred way.3 The TR route offers better procedure comfort, shorter hospitalization […]

The prognostic value of estimated glomerular filtration rate, amino-terminal portion of the pro-hormone B-type natriuretic peptide and parameters of cardiopulmonary exercise testing in patients with chronic heart failure

Hein J. Verberne, Aukje van der Spank, Paul Bresser, Aernout Somsen
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Published Online: Aug 7th 2018 Heart International 2012;7(2):e13 DOI: https://doi.org/10.4081/hi.2012.e13
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Abstract

Overview

The aim of this study was to evaluate the
prognostic value of renal function in relation
to amino-terminal portion of the pro-hormone
B-type natriuretic peptide (NTproBNP)
and parameters of cardiopulmonary
exercise testing in predicting mortality and
morbidity in patients with moderate chronic
heart failure (CHF). Sixty-one CHF patients
were included in the study. Patients’ characteristics
were: age 64.3±11.6 years; New York
Heart Association class I/II/III: 14/37/10; left
ventricular ejection fraction: 0.30±0.13 (%);
NT-proBNP: 252.2±348.0 (ng/L); estimated
creatinine clearance (e-CC): 73.6±31.4
(mL/min); estimated glomerular filtration
rate (e-GFR): 66.1±24.6 (mL/min/1.73 m2);
the highest O2 uptake during exercise (VO2
peak): 1.24±0.12 mL/kg/min; VO2/workload:
8.52±1.81 (mL/min/W)]. During follow up
(59.5±4.0 months) there were 15 cardiac
deaths and 16 patients were hospitalized due
to progression of heart failure. NT-proBNP
and VO2/workload were independently associated
with cardiac death (P=0.007 and
P=0.006, respectively). Hospitalization for
progressive CHF was only associated with
NT-proBNP (P=0.002). The combined cardiac
events (cardiac death and hospitalization)
were associated with NT-proBNP and VO2/
workload (P=0.007 and P=0.005, respectively).
The addition of estimates of renal function
(neither serum creatinine nor e-GFR)
did not improve the prognostic value for any
of the models.In conclusion, in patients with
moderate CHF, increased NT-proBNP and
reduced VO2/ workload identify those with
increased mortality and morbidity, irrespective
of estimates of renal function.

Keywords

VO2, workload, NT-proBNP, prognosis, chronic heart failure, renal function

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Article Information

Correspondence

Hein J. Verberne, Department of Nuclear Medicine, Room F2-238, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands. Tel. +31.20.5669111 – Fax: +31.20.5669092. E-mail: h.j.verberne@amc.uva.nl

Received

2011-10-25T00:00:00

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