Computer-aided analysis of 64-slice coronary computed tomography angiography: a comparison with manual interpretation
Abstract
Overview
Coronary computed tomography angiography
(CCTA) is increasingly used for the
assessment of coronary heart disease (CHD)
in symptomatic patients. Software applications
have recently been developed to facilitate
efficient and accurate analysis of CCTA.
This study aims to evaluate the clinical application
of computer-aided diagnosis (CAD)
software for the detection of significant coronary
stenosis on CCTA in populations with low
(8%), moderate (13%), and high (27%) CHD
prevalence. A total of 341 consecutive patients
underwent 64-slice CCTA at 3 clinical sites in
the United States. CAD software performed
automatic detection of significant coronary
lesions (>50% stenosis). CAD results were
then compared to the consensus manual interpretation
of 2 imaging experts. Data analysis
was conducted for each patient and segment.
The CAD had 100% sensitivity per patient
across all 3 clinical sites. Specificity in the low,
moderate, and high CHD prevalence populations
was 64%, 41%, and 38%, respectively.
The negative predictive value at the 3 clinical
sites was 100%. The positive predictive value
was 22%, 21%, and 38% for the low, moderate,
and high CHD prevalence populations, respectively.
This study demonstrates the utility of
CAD software in 3 distinct clinical settings. In
a low-prevalence population, such as seen in
the emergency department, CAD can be used
as a Computer-Aided Simple Triage tool to
assist in diagnostic delineation of acute chest
pain. In a higher prevalence population, CAD
software is useful as an adjunct for both the
experienced and inexperienced reader.
Keywords
Coronary computed tomography angiography, coronary heart disease, computed aided diagnosis.
Article Information
Correspondence
Michael Poon, Department of Radiology, School of Medicine, Stony Brook University Medical Center, HSC, Level 4, Room 120, Stony Brook, NY 11794-8460, USA. Tel. +01.631.444.9565 – Fax: +01.631.444.7538. E-mail: michael.poon@stonybrookmedicine.edu
Received
2012-09-20T00:00:00
Further Resources
Trending Topic
As of the publication of this article, the coronavirus disease 2019 (COVID-19) infection has affected over 400 million people around the world and caused over 6 million deaths.1Â Although COVID-19 infection predominantly affects the respiratory system, studies have described a wide spectrum of cardiovascular manifestations, including asymptomatic myocardial injury, myocardial infarction and myocarditis.2Â Echocardiography is an easily […]
More than half of acute coronary syndromes (ACS) occur in subjects with no significant coronary stenosis.1Â In view of the number of patients dying each year from a heart attack, the question of identifying these patients is of primary importance. ...
Left main Stenosis Stenting Normalizes Wall Shear Stress of Ascending Aorta in Bicuspid Aortic Valve
Bicuspid aortic valve (BAV) represents the most common congenital cardiac anomaly, with a prevalence ranging between 1% and 2% in the general population.1Â BAV is known to be associated with dilation and dissection of the ascending aorta, and the significantly higher shear ...
Anomalous coronary arteries originating from the opposite sinus of Valsalva (ACAOS) is one of the most clinically relevant abnormalities among the wide spectrum of coronary artery anomalies.1Â Sudden cardiac death has been related to myocardial bridges, ectopic origin of the ...
Introduction:Â The restriction of activation mapping to the ventricular surface of contemporary mapping systems often leads to failure to correctly identify the true site of origin (SOO) of intramural and/or sub-epicardial Vas and lower procedural success. Electromechanical wave imaging (...
Introduction: Leadless left ventricular (LV) endocardial pacing with the WiSE-CRT System (EBR Systems Inc) is a novel treatment in the field of cardiac resynchronization therapy (CRT). The system was designed to provide lateral wall LV pacing (LVP) in response to ...
Background:Â The spatial resolution of a mapping catheter is determined by factors such as the quantity of electrodes, their inter-electrode spacing, and the various configurations in which they are utilized. These factors impact the interpretation of wavefront dynamics during cardiac ...
Background:Â Obesity-related cardiac remodelling may be reflected through electrocardiogram (ECG) changes. Based on this premise, we hypothesised that an artificial intelligence (AI)-ECG model could be trained to predict body mass index (BMI), and that the difference between AI-ECG predicted ...
Athletes represent the fittest individuals in our society, yet paradoxically carry an increased risk of sudden cardiac death (SCD) when compared to sedentary individuals with the same cardiac disease.1,2 Two recent studies have provided a realistic prevalence of young SCD ...
Sudden cardiac death arises from the unexpected stopping of the heart and is associated with up to a half of cardiovascular deaths. We discuss with Professor Martin Borggrefe how to identify patient populations at risk of sudden cardiac death (...
Brugada syndrome (BrS) is a genetic arrhythmia syndrome with increased risk of sudden cardiac death. Unmasking a type I BrS electrocardiogram (ECG) pattern after administration of sodium channel blockers may be associated with an increase in epicardial substrate abnormalities. We ...
...
...
Log into your Touch Account
Earn and track your CME credits on the go, save articles for later, and follow the latest congress coverage.
Sign up with an Email
Or use a .
This Functionality is for
Members Only
Explore the latest in medical education and stay current in your field. Create a free account to track your learning.
