Trending Topic

15 mins

Trending Topic

Developed by Touch
Mark CompleteCompleted
BookmarkBookmarked

Cardiovascular diseases are the most common cause of mortality and morbidity in adults worldwide.1 Coronary angiography (CAG) is the gold standard method for evaluating atherosclerotic coronary artery disease (CAD).2 It is conventionally performed via the trans-femoral (TF) route. Recently, however, the trans-radial (TR) route has become the preferred way.3 The TR route offers better procedure comfort, shorter hospitalization […]

B-type natriuretic peptide predicts long-term prognosis in a cohort of critically ill patients

Rui Baptista, Elisabete Jorge, Eduardo Sousa, Jorge Pimentel
Share
Facebook
X (formerly Twitter)
LinkedIn
Via Email
Mark CompleteCompleted
BookmarkBookmarked
Copy LinkLink Copied
Download as PDF
Published Online: Aug 7th 2018 Heart International 2011;6(2):e18 DOI: https://doi.org/10.4081/hi.2011.e18
Select a Section…
1

Abstract

Overview

B-type natriuretic peptide is an important
prognostic marker in heart failure. However,
there are limited data for its value in non-cardiac
intensive care unit patients, namely
regarding long-term prognosis. We investigated
the long-term prognostic value of BNP in a
cohort of critically ill patients. This was a
prospective and observational study, conducted
in a tertiary university hospital 20-bed
intensive care unit. We included 103 mechanically-
ventilated patients admitted for a noncardiac
primary diagnosis; B-type natriuretic
peptide samples were obtained on admission.
A mean 14 (3-30) month follow up was available
in 96.1% of patients who were discharged
from hospital. Mean age was 60.7±19.0 years
and mean APACHE II score was 16.2±7.2.
APACHE II score and renal dysfunction
increased with rising B-type natriuretic peptide,
with more than 60% of patients having Btype
natriuretic peptide levels of 100 pg/mL or
over; echocardiography-derived left ventricular
ejection fraction was lower in patients with
higher B-type natriuretic peptide (P < 0.001). Long-term survivors had lower median B-type natriuretic peptide values (117.5[2-1668] pg/mL) compared with intensive care unit non-survivors (191.0[5-4945] pg/mL), P<0.001. After adjustment to APACHE II score, B-type natriuretic peptide levels of 300 pg/mL or over were independently associated with long-term mortality (odds-ratio 4.1 [95% CI 1.45-11.5], P=0.008). We conclude that in an unselected cohort of intensive care unit patients, admission B-type natriuretic peptide is frequently elevated, even without clinically apparent acute heart disease, and is a strong independent predictor of long-term mortality.

Keywords

BNP, critical illness, prognosis, mortality.

2

Article Information

Correspondence

Rui Baptista Cardiology Department, Coimbra University Hospital and Medical School Praceta Mota Pinto, 3000-001 Coimbra, Portugal. Tel: + 351.918523940. E-mail: ruibaptista@gmail.com

Acknowledgements

We are indebted to the ICU
nursing staff, for substantial help in blood sample
withdrawal and processing.

Received

2011-05-15T00:00:00

3

Further Resources

Share
Facebook
X (formerly Twitter)
LinkedIn
Via Email
Mark CompleteCompleted
BookmarkBookmarked
Copy LinkLink Copied
Download as PDF
Close Popup