Correlation of pulse wave velocity with left ventricular mass in patients with hypertension once blood pressure has been normalized
Abstract
Overview
Vascular stiffness has been proposed as a
simple method to assess arterial loading conditions
of the heart which induce left ventricular
hypertrophy (LVH). There is some controversy
as to whether the relationship of vascular
stiffness to LVH is independent of blood
pressure, and which measurement of arterial
stiffness, augmentation index (AI) or pulse
wave velocity (PWV) is best. Carotid pulse
wave contor and pulse wave velocity of
patients (n=20) with hypertension whose
blood pressure (BP) was under control
(<140/90 mmHg) with antihypertensive drug
treatment medications, and without valvular
heart disease, were measured. Left ventricular
mass, calculated from 2D echocardiogram,
was adjusted for body size using two different
methods: body surface area and height. There
was a significant (P<0.05) linear correlation
between LV mass index and pulse wave velocity.
This was not explained by BP level or lower
LV mass in women, as there was no significant
difference in PWV according to gender
(1140.1+67.8 vs 1110.6+57.7 cm/s). In contrast
to PWV, there was no significant correlation
between LV mass and AI. In summary,
these data suggest that aortic vascular stiffness
is an indicator of LV mass even when
blood pressure is controlled to less than 140/90
mmHg in hypertensive patients. The data further
suggest that PWV is a better proxy or surrogate
marker for LV mass than AI and the
measurement of PWV may be useful as a rapid
and less expensive assessment of the presence
of LVH in this patient population.
Keywords
Left ventricular mass, hypertension, pulse wave velocity, arterial stiffness.
Article Information
Correspondence
Simon W. Rabkin, Department of Medicine, Division of Cardiology, University of British Columbia, Level 9 2775 Laurel St, Vancouver, B.C., V5Z 1M9, Canada. Tel. +1.604.875.5847 – Fax: +1.875.5849. E-mail: rabkin@mail.ubc.ca
Received
2011-05-09T00:00:00
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