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Cardiovascular diseases are the most common cause of mortality and morbidity in adults worldwide.1 Coronary angiography (CAG) is the gold standard method for evaluating atherosclerotic coronary artery disease (CAD).2 It is conventionally performed via the trans-femoral (TF) route. Recently, however, the trans-radial (TR) route has become the preferred way.3 The TR route offers better procedure comfort, shorter hospitalization […]

Discovering a new role for the atrial natriuretic peptide: A novel risk factor for cardiovascular diseases

Speranza Rubattu, Massimo Volpe
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Published Online: Jul 26th 2018 Heart International 2006;2(2):78-81
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Abstract

Overview

Atrial natriuretic peptide, a diuretic, natriuretic and vasorelaxant hormone, is also
involved in the regulation of cardiovascular remodeling and it has been recently shown to be significantly
associated with higher occurrence of cardiovascular diseases. In fact, high plasma
ANP levels predict higher mortality rate for cardiovascular events. Moreover, ANP gene alterations
are associated with higher risk of cardiovascular intermediate phenotypes, such as left
ventricular hypertrophy, and of cardiovascular diseases, such as stroke and hypertension.
Thus, the characterization of ANP plasma levels, and of ANP genotype for known mutations can
be proposed as an informative component of the individual cardiovascular risk profile. (Heart International
2006; 2: 78-81)

Keywords

Atrial natriuretic peptide, Cardiovascular risk, Genetic

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Article Information

Correspondence

Speranza Rubattu, MD, IRCCS Neuromed, Località Camerelle-Zona Industriale, 86077 Pozzilli (IS) – Italy, rubattu.speranza@neuromed.it

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