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Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide.1 High systolic blood pressure (SBP) remains one of the top risk factors for CVD burden globally.2 Despite being a modifiable risk factor, hypertension (HTN) remains largely undiagnosed and untreated due to inadequate screening, poor awareness and lack of treatment adherence.3 Globally, HTN is undiagnosed in about 46% […]

Discovering a new role for the atrial natriuretic peptide: A novel risk factor for cardiovascular diseases

Speranza Rubattu, Massimo Volpe
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Published Online: Jul 26th 2018 Heart International 2006;2(2):78-81
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Abstract

Overview

Atrial natriuretic peptide, a diuretic, natriuretic and vasorelaxant hormone, is also
involved in the regulation of cardiovascular remodeling and it has been recently shown to be significantly
associated with higher occurrence of cardiovascular diseases. In fact, high plasma
ANP levels predict higher mortality rate for cardiovascular events. Moreover, ANP gene alterations
are associated with higher risk of cardiovascular intermediate phenotypes, such as left
ventricular hypertrophy, and of cardiovascular diseases, such as stroke and hypertension.
Thus, the characterization of ANP plasma levels, and of ANP genotype for known mutations can
be proposed as an informative component of the individual cardiovascular risk profile. (Heart International
2006; 2: 78-81)

Keywords

Atrial natriuretic peptide, Cardiovascular risk, Genetic

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Article Information

Correspondence

Speranza Rubattu, MD, IRCCS Neuromed, Località Camerelle-Zona Industriale, 86077 Pozzilli (IS) – Italy, rubattu.speranza@neuromed.it

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