Discovering a new role for the atrial natriuretic peptide: A novel risk factor for cardiovascular diseases
Abstract
Overview
Atrial natriuretic peptide, a diuretic, natriuretic and vasorelaxant hormone, is also
involved in the regulation of cardiovascular remodeling and it has been recently shown to be significantly
associated with higher occurrence of cardiovascular diseases. In fact, high plasma
ANP levels predict higher mortality rate for cardiovascular events. Moreover, ANP gene alterations
are associated with higher risk of cardiovascular intermediate phenotypes, such as left
ventricular hypertrophy, and of cardiovascular diseases, such as stroke and hypertension.
Thus, the characterization of ANP plasma levels, and of ANP genotype for known mutations can
be proposed as an informative component of the individual cardiovascular risk profile. (Heart International
2006; 2: 78-81)
Keywords
Atrial natriuretic peptide, Cardiovascular risk, Genetic
Article Information
Correspondence
Speranza Rubattu, MD, IRCCS Neuromed, Località Camerelle-Zona Industriale, 86077 Pozzilli (IS) – Italy, rubattu.speranza@neuromed.it
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