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Native valve infective endocarditis (IE) is rare, with an incidence of 3–7 cases per 100,000 person-years.1,2 Cardiac structural complications from local infection extension include valvular destruction, peri-annular abscess and fistula formation. Left ventricular pseudoaneurysm (LVP) from IE is exceedingly rare, occurring in <1% of cases, and is associated with high morbidity and mortality. Diagnosis is challenging due to nonspecific symptoms […]

Marie-Sophie de Koning, ACC 2022: GIPS-IV: The Groningen Intervention Study For the Preservation of Cardiac Function With Sodium Thiosulfate After ST-segment Elevation Myocardial Infarction

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Published Online: May 3rd 2022

The Groningen Intervention study for the Preservation of cardiac function with STS after STEMI (GIPS-IV) trial is a double-blind, randomized, placebo-controlled, multicenter trial. touchCARDIO speaks with Dr Marie-Sophie de Koning (University of Groningen, Groningen, The Netherlands) to discuss her presentation of the GIPS-IV trial and to highlight the rationale, design, and study findings.

Questions: Marie-Sophie de Koning has nothing to disclose in relation to this video.

  1. What is the rationale for the use of hydrogen sulphide in patients after ST-segment Elevation Myocardial Infarction (STEMI)? (00:19)
  2. What are the aims and design of the GIPS-IV trial? (01:05)
  3. What are the clinical endpoints and eligibility findings of the study? (02:08)
  4. What are the study findings to date? (02:38)

Disclosures: Marie-Sophie de Koning has nothing to disclose in relation to this video.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Shanice Allen.

Filmed in coverage of the American College of Cardiology Annual Meeting 2022

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