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Ventricular fibrillation (VF) is characterized by rapid (>300 beats a per minute), irregular electrical activation with variable electrocardiographic waveforms that prevents coordinated myocardial contraction, resulting in immediate loss of cardiac output.1 It most commonly occurs in the context of coronary artery disease.2,3 Resuscitation efforts are critically time-dependent: with each minute of untreated VF, the survival rate declines […]

Aldo Pietro Maggioni, ESC 2019 – Oral Anticoagulants and Ischaemic Stroke in Atrial Fibrillation

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Published Online: Sep 4th 2019

We spoke to Dr Aldo Pietro Maggioni (Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO) Research Center, Florence, Italy) about the key observations from his study of trends in oral anticoagulant use and the rate of ischaemic stroke in people with atrial fibrillation. He also discussed how big data can provide insight and what he expects to see from real-world observations, as well as how this may affect routine practice.

Speaker’s Disclosures: Aldo Pietro Maggioni has nothing to declare in relation to this video interview.

Questions:
1. What were the key observations in your study of trends in oral anticoagulant use and rate of ischaemic stroke over a 4-year period in 194,030 people with atrial fibrillation? (0:04)
2. How can ‘big data’ provide insight beyond randomised clinical trials and registry studies? (1:59)
3. What findings do you expect to emerge from large-scale real-world observations, and how can these findings help cardiovascular physicians in routine practice? (3:28)

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Filmed at the European Society of Cardiology (ESC) Congress 2019 in Paris, France, September 2019.

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