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Ventricular fibrillation (VF) is characterized by rapid (>300 beats a per minute), irregular electrical activation with variable electrocardiographic waveforms that prevents coordinated myocardial contraction, resulting in immediate loss of cardiac output.1 It most commonly occurs in the context of coronary artery disease.2,3 Resuscitation efforts are critically time-dependent: with each minute of untreated VF, the survival rate declines […]

Michael Miller, ESC 2022: Icosapent ethyl for smoking, the REDUCE-IT study

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Published Online: Sep 9th 2022

The REDUCE-IT study evaluated the effects of icosapent ethyl on cardiovascular risk in patients with a history of smoking. In this touchCARDIO interview, we speak with Dr Michael Miller (Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA) to discuss the REDUCE-IT study and n–3 fatty acid supplementation. 

The abstract entitled ‘Icosapent Ethyl diminishes CVD risk in smokers: REDUCE-IT smoking’ was presented at the European Society of Cardiology (ESC) Congress 2022, 26 – 29 August 2022.

Questions:

  1. Could you give us a brief overview of the REDUCE-IT study and its overall findings? (0:31)
  2. Why do you think this trial had positive findings when other studies with n–3 fatty acid supplementation have failed? (2:06)

Disclosures: Michael Miller is a consultant for Amarin.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Danielle Crosby.

Filmed as a highlight of ESC 2022

Access more content on Cardiovascular Risk here

Additional Resources: Miller M, Bhatt DL, Steg PG, et al. Potential effects of icosapent ethyl on cardiovascular outcomes in cigarette smokers: REDUCE-IT smoking. Eur Heart J Cardiovasc Pharmacother. 2022;pvac045. doi: 10.1093/ehjcvp/pvac045

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