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Ventricular fibrillation (VF) is characterized by rapid (>300 beats a per minute), irregular electrical activation with variable electrocardiographic waveforms that prevents coordinated myocardial contraction, resulting in immediate loss of cardiac output.1 It most commonly occurs in the context of coronary artery disease.2,3 Resuscitation efforts are critically time-dependent: with each minute of untreated VF, the survival rate declines […]

Milind Desai, ACC 2022: VALOR-HCM trial

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Published Online: May 3rd 2022

The VALOR-HCM trial showed the benefits of  mavacamten as an alternative to surgical septal myectomy or alcohol ablation in patients with severely symptomatic obstructive hypertrophic cardiomyopathy. It was a pleasure to speak with Prof. Milind Desai (Cleveland Clinic, Cleveland, OH) about the VALOR-HCM trial including the efficacy and safety endpoints of it and what future studies of mavacamten are planned.

Questions:

  1. Could you tell us a little about the VALOR-HCM trial? (00:21)
  2. What questions remain unanswered about the health benefits of mavacamten, and what future studies are planned? (04:45)

Disclosures: Milind Desai is a consultant for Bristol Myers Squibb and Medtronic.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Shanice Allen.

Filmed in coverage of the American College of Cardiology Annual Meeting 2022

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