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Native valve infective endocarditis (IE) is rare, with an incidence of 3–7 cases per 100,000 person-years.1,2 Cardiac structural complications from local infection extension include valvular destruction, peri-annular abscess and fistula formation. Left ventricular pseudoaneurysm (LVP) from IE is exceedingly rare, occurring in <1% of cases, and is associated with high morbidity and mortality. Diagnosis is challenging due to nonspecific symptoms […]

Milind Desai, ACC 2022: VALOR-HCM trial

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Published Online: May 3rd 2022

The VALOR-HCM trial showed the benefits of  mavacamten as an alternative to surgical septal myectomy or alcohol ablation in patients with severely symptomatic obstructive hypertrophic cardiomyopathy. It was a pleasure to speak with Prof. Milind Desai (Cleveland Clinic, Cleveland, OH) about the VALOR-HCM trial including the efficacy and safety endpoints of it and what future studies of mavacamten are planned.

Questions:

  1. Could you tell us a little about the VALOR-HCM trial? (00:21)
  2. What questions remain unanswered about the health benefits of mavacamten, and what future studies are planned? (04:45)

Disclosures: Milind Desai is a consultant for Bristol Myers Squibb and Medtronic.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Shanice Allen.

Filmed in coverage of the American College of Cardiology Annual Meeting 2022

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