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Ventricular fibrillation (VF) is characterized by rapid (>300 beats a per minute), irregular electrical activation with variable electrocardiographic waveforms that prevents coordinated myocardial contraction, resulting in immediate loss of cardiac output.1 It most commonly occurs in the context of coronary artery disease.2,3 Resuscitation efforts are critically time-dependent: with each minute of untreated VF, the survival rate declines […]

Mandeep Mehra, ESC 2022: HeartMate 3™ left ventricular assist device for heart failure, the MOMENTUM 3 study 2- and 5-year results

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Published Online: Sep 9th 2022

Following its positive 2-year results, the MOMENTUM 3 study in patients with heart failure was extended to assess 5-year outcomes of the HeartMate 3™ left ventricular assist device. In this touchCARDIO interview, we speak with Dr Mandeep Mehra (Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA) to discuss the MOMENTUM 3 study and its findings at both 2 and 5 years.

The abstract entitled ‘5-year Survival with LVAD Therapy in MOMENTUM 3’ was presented at the European Society of Cardiology (ESC) Congress 2022, 26 – 29 August 2022.

Questions:

  1. What were the aims, design and eligibility criteria of the MOMENTUM 3 study? (0:21)
  2. What were the study efficacy and outcomes and how well were they achieved at 2 years? (5:19)
  3. What have been the 5-year findings, and have any late complications emerged? (7:37)

Disclosures: Mandeep Mehra is a consultant for Abbott, Janssen, Mesoblast, Medtronic, Natera and Paragonix and is on the advisory board for FineHeart, Leviticus, NupulseCV and Transmedics. 

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Danielle Crosby.

Filmed as a highlight of ESC 2022

Access more content on Devices here and Heart Failure here

Additional Resources: Mehra MR, Goldstein DJ, Cleveland JC, et al. Five-Year Outcomes in Patients With Fully Magnetically Levitated vs Axial-Flow Left Ventricular Assist Devices in the MOMENTUM 3 Randomized Trial. JAMA. 2022; doi: 10.1001/jama.2022.16197.

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