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The foramen ovale, an obligatory channel, allows placental oxygenated blood to directly reach the fetal arterial circulation and remains patent in 25% of the adult population.1 Patency provides a potential gateway for venous emboli to reach the arterial circulation, potentially resulting in systemic embolus or stroke (now termed ‘patent foramen ovale [PFO]-associated stroke’).2 Preventive strategies for recurrent […]

Mandeep Mehra, ESC 2022: HeartMate 3™ left ventricular assist device for heart failure, the MOMENTUM 3 study 2- and 5-year results

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Published Online: Sep 9th 2022

Following its positive 2-year results, the MOMENTUM 3 study in patients with heart failure was extended to assess 5-year outcomes of the HeartMate 3™ left ventricular assist device. In this touchCARDIO interview, we speak with Dr Mandeep Mehra (Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA) to discuss the MOMENTUM 3 study and its findings at both 2 and 5 years.

The abstract entitled ‘5-year Survival with LVAD Therapy in MOMENTUM 3’ was presented at the European Society of Cardiology (ESC) Congress 2022, 26 – 29 August 2022.

Questions:

  1. What were the aims, design and eligibility criteria of the MOMENTUM 3 study? (0:21)
  2. What were the study efficacy and outcomes and how well were they achieved at 2 years? (5:19)
  3. What have been the 5-year findings, and have any late complications emerged? (7:37)

Disclosures: Mandeep Mehra is a consultant for Abbott, Janssen, Mesoblast, Medtronic, Natera and Paragonix and is on the advisory board for FineHeart, Leviticus, NupulseCV and Transmedics. 

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Danielle Crosby.

Filmed as a highlight of ESC 2022

Access more content on Devices here and Heart Failure here

Additional Resources: Mehra MR, Goldstein DJ, Cleveland JC, et al. Five-Year Outcomes in Patients With Fully Magnetically Levitated vs Axial-Flow Left Ventricular Assist Devices in the MOMENTUM 3 Randomized Trial. JAMA. 2022; doi: 10.1001/jama.2022.16197.

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