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Cardiovascular medicine stands at a pivotal crossroads—shaped by rapid advances in precision therapies, a deepening understanding of disease mechanisms, and an urgent imperative to address global health disparities. As the burden of cardiovascular disease continues to evolve, so too does the need for nuanced, evidence-based approaches that span the full spectrum of care: from prevention […]

HEART INTERNATIONAL – VOLUME 13 ISSUE 2 – WINTER 2019

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Foreword

Welcome to the winter 2019 issue of Heart International! I hope you will enjoy reading the selection of articles we have included in this edition. We open with a letter from my co-Editor-in-Chief, Dr Rajesh Davé, focusing on the recently forged partnership between the journal and the International Complex Cardiovascular Catheter Therapeutics (C3) conference. This […]

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Letter

2 mins
Rajesh Davé

Dear Colleagues, Welcome to the winter 2019 edition of Heart International. Here, I look forward to describing, in more detail, the partnership between touchCARDIO, Heart International and the Complex Cardiovascular Catheter Therapeutics (C3) congress – as well as introducing this edition of the journal and its interesting, practical and educational content. Official partnership with C3 […]

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Review

8 mins
Marshall J Heradien, Pieter van der Bijl, Paul A Brink

Hypertension is a global health problem, with an estimated 1.13 billion individuals affected.1 Patients with hypertension, especially when resistant to conventional therapy, are at high risk of sequelae, e.g., ischaemic heart disease, haemorrhagic and ischaemic stroke, cardiac failure, peripheral vascular disease and end-stage renal disease.2 Renal denervation (RD) is an emerging treatment modality which allows […]

Coronary artery disease (CAD) is a major global cause of death attributing to nearly 9 million deaths worldwide in 2016.1 The introduction of percutaneous coronary intervention (PCI) has revolutionised the treatment of CAD in current clinical practice, and advances in coronary stent technology have continued to deliver improved outcomes. In recent years, there has been […]

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Original Research

First described in Japan in 1990, takotsubo or stress cardiomyopathy (SC), has become one of most commonly described forms of cardiomyopathy in the literature over the past two decades.1 Typically, patients with SC present with angina or other acute cardiac symptoms in the setting of significant physical or mental stressors and transient myocardial dysfunction which […]

In individuals with heart failure (HF) who also have implanted cardioverter defibrillators and/or cardiac resynchronisation therapy (ICD/CRT) devices, low daily physical activity (PA) levels lead to increased risk of mortality, poor aerobic capacity and lower health-related quality of life.1 Improving daily PA in these individuals may, therefore, be an important clinical endpoint; however, designing interventional […]

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Case Report

Fractional flow reserve (FFR) has been a useful tool in guiding decision-making in intermediate left main coronary artery (LMCA) stenosis, particularly in the absence of downstream disease.1 Multiple caveats have been raised about the use of FFR with significant downstream disease and the interpretation of the significance of the LMCA stenosis.2 On the other hand, […]

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