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Native valve infective endocarditis (IE) is rare, with an incidence of 3–7 cases per 100,000 person-years.1,2 Cardiac structural complications from local infection extension include valvular destruction, peri-annular abscess and fistula formation. Left ventricular pseudoaneurysm (LVP) from IE is exceedingly rare, occurring in <1% of cases, and is associated with high morbidity and mortality. Diagnosis is challenging due to nonspecific symptoms […]

Caroline Sindet-Pedersen, ESC 2022: SARS-CoV-2 mRNA vaccines in patients with heart failure

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Published Online: Sep 20th 2022

Studies investigating the safety and efficacy of the severe acute respiratory syndrome coronavirus 2 infection (SARS-CoV-2) mRNA vaccines lacked representation of patients with heart failure. In this touchCARDIO interview, we speak with Dr Caroline Sindet-Pedersen (Copenhagen University Hospital Herlev and Gentofte, Hellerup, Denmark) to discuss the study presented at ESC 2022 that aimed to investigate the risk of worsening heart failure and all-cause mortality associated with the SARS-CoV-2 mRNA vaccines in a Danish nationwide cohort of patients with heart failure.

The abstract entitled ‘COVID mRNA vaccines are safe in patients with heart failure’ was presented at the European Society of Cardiology (ESC) Congress 2022, 26 – 29 August 2022.

Questions:

  1. What is known about the risks of adverse COVID-19 outcomes in heart failure patients? (0:17)
  2. What are the common perceptions of cardiovascular side effects from mRNA vaccinations and what evidence supports these perceptions? (0:48)
  3. What were the aims, design and patient population of the study you are presenting? (1:31)
  4. How did the risks of adverse outcomes compare in the two groups? (2:38)
  5. What is the key take-home message of these findings? (3:21)

Disclosures: Caroline Sindet-Pedersen has nothing to disclose in relation to this video interview.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Danielle Crosby.

Filmed as a highlight of ESC 2022

Access more content on COVID-19 here and Heart Failure here

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