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Ventricular fibrillation (VF) is characterized by rapid (>300 beats a per minute), irregular electrical activation with variable electrocardiographic waveforms that prevents coordinated myocardial contraction, resulting in immediate loss of cardiac output.1 It most commonly occurs in the context of coronary artery disease.2,3 Resuscitation efforts are critically time-dependent: with each minute of untreated VF, the survival rate declines […]

Heart rate turbulence and variability in patients with ventricular arrhythmias

Federico Lombardi, Fabrizio Tundo, Abdalrahim Abukwaik, Diego Tarricone
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Published Online: Jul 27th 2018 Heart International 2007;3(1-2):51-7
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Abstract

Overview

Background. To evaluate the changes in autonomic neural control mechanisms before
malignant ventricular arrhythmias, we measured heart rate variability (HRV) and heart rate
turbulence (HRT) in patients with ventricular tachycardia or fibrillation (Group I; n=6), non sustained
ventricular tachycardia (Group II; n=32), frequent premature ventricular beats (Group III;
n=26) and with ICD implantation (Group IV; n=11).
Methods. Time domain parameters of HRV and turbulence onset (TO) and slope (TS) were calculated
on 24 hour Holter recordings. Normal values were: SDNN > 70 msec for HRV, TO <0% and TS >2.5 msec/RR-I for HRT.
Results. Whereas SDNN was within normal range and similar in all study groups, HRT parameters
were significantly different in patients who experienced VT/VF during Holter recording. Abnormal
TO and/or TS were present in 100% of Group I patients and only in about 50% of Group
II and IV. On the contrary, normal HRT parameters were present in 40-70% of Group II, III and IV
patients and none of Group I.
Conclusions. These data suggest that HRT analysis is more suitable than HRV to detect those
transient alterations in autonomic control mechanisms that are likely to play a major trigger role
in the genesis of malignant cardiac arrhythmias. (Heart International 2007; 3: 51-7)

Keywords

Sudden cardiac death, Autonomic nervous system, Risk stratification, Ventricular fibrillation, Holter recordings

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Article Information

Correspondence

Prof. Federico Lombardi, MD, FESC Cardiologia, Dipartimento di Medicina, Chirurgia e Odontoiatria, Osp. San Paolo, Università di Milano, Via A. di Rudinì, 8, 20142 Milano – Italy, Federico.Lombardi@unimi.it

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