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Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide.1 High systolic blood pressure (SBP) remains one of the top risk factors for CVD burden globally.2 Despite being a modifiable risk factor, hypertension (HTN) remains largely undiagnosed and untreated due to inadequate screening, poor awareness and lack of treatment adherence.3 Globally, HTN is undiagnosed in about 46% […]

Marked prolongation of QRS duration after initiation of dronedarone therapy

Conrad Genz, Hans D. Esperer, Alexander Schmeisser, Ruediger C. Braun-Dullaeus, Samir M. Said
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Published Online: Aug 10th 2018 Heart International 2014;9(1):33-35 DOI: https://doi.org/10.5301/HEART.2014.12491
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1

Abstract

Overview

Dronedarone is a relatively new antiarrhythmic drug and is held to be less proarrhythmic than comparable compounds,
although its proarrhythmia potential in humans has not been sufficiently evaluated. We describe a so far
unreported dronedarone effect, namely a significant alteration of both the morphology and the duration of the
QRS complex on the electro cardiogram in a 41-year old patient with symptomatic paroxysmal atrial fibrillation.

Keywords

Adverse drug events, Antiarrhythmic drugs, Atrial fibrillation, Dronedarone.

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Article Information

Correspondence

Samir M. Said, Otto-von-Guericke University University Hospital, Centre of Internal Medicine Division of Cardiology Leipziger Str. 44 39120 Magdeburg, Germany samir.said@med.ovgu.de

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