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Native valve infective endocarditis (IE) is rare, with an incidence of 3–7 cases per 100,000 person-years.1,2 Cardiac structural complications from local infection extension include valvular destruction, peri-annular abscess and fistula formation. Left ventricular pseudoaneurysm (LVP) from IE is exceedingly rare, occurring in <1% of cases, and is associated with high morbidity and mortality. Diagnosis is challenging due to nonspecific symptoms […]

Anemia and heart failure: a cause of progression or only a consequence?

Marco Metra, Savina Nodari, Tania Bordonali, Silvia Bugatti, Benedetta Fontanella, Carlo Lombardi, Alberto Saporetti, Giulia Verzura, Rossella Danesi, Livio Dei Cas
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Published Online: Jul 27th 2018 Heart International 2007;3(1-2):1-11
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Abstract

Overview

Anemia is one of the most frequent co-morbidities in the patients with heart failure.
Its prevalence increases from 4-7% in the subjects with asymptomatic left ventricular dysfunction
to >30% in the patients with severe heart failure. Renal insufficiency, activation of inflammatory
mediators, and treatment with renin-angiotensin antagonists seem to be its main determinants.
The results of many studies agree in showing that anemia is a powerful independent determinant
of survival in patients with heart failure. However, the mechanisms of this relation are
still incompletely understood. Moreover a favourable effect on prognosis of the correction of
anemia has not been shown, yet, and also controlled studies assessing its effects on exercise
tolerance have yielded controversial results. (Heart International 2007; 3: 1-11)

Keywords

Anemia, Heart failure, Prognosis, Erythropoietin

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Article Information

Correspondence

Prof. Marco Metra, Section of Cardiovascular Diseases, Dept. Of Experimental and Applied Medicine, University of Brescia c/o Spedali Civili, P.zza Spedali Civili, 1, 25123 Brescia – Italy, metramarco@libero.it

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