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Hypertension is the leading modifiable risk factor for global cardiovascular disease, responsible for an estimated 10.8 million deaths and more than 200 million disability-adjusted life years annually.1 Despite the availability of effective pharmacological and lifestyle interventions, prevalence continues to rise, particularly in low- and middle-income countries (LMICs), where over three-quarters of all cases now occur.2 The condition’s […]

Non-compaction of the ventricular myocardium

Enrico Vizzardi, Savina Nodari, Marco Metra, Livio Dei Cas
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Published Online: Jul 26th 2018 Heart International 2006;2(3-4):178-83
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Abstract

Overview

Non-compaction of the left ventricle (LVNC) is a disorder of endomyocardial morphogenesis
that results in multiple trabeculations in the left ventricular (LV) myocardium. This
rare disorder is characterized by an excessively prominent trabecular meshwork and deep intratrabecular
recesses. This idiopathic cardiomyopathy is characterized by an altered structure of
the myocardial wall as a result of intrauterine arrest of compaction of the myocardial fibers in the
absence of any coexisting congenital lesion. It can be associated with neuromuscular disorders
and can co-exist with other cardiac malformations, and it is accompanied by depressed ventricular
function, systemic embolism and ventricular arrhythmia. Echocardiography is the method of
choice for diagnosing LVNC, but the correct diagnosis is often missed or delayed due to a lack
of knowledge concerning this uncommon disease and its similarity to other diseases of the myocardium
and endocardium. There is a two-layered structure of the myocardial wall consisting of
a thin compacted epicardial layer and a thick non-compacted endocardial layer with prominent
trabeculations and deep recesses. (Heart International 2006; 3-4: 178-83)

Keywords

Cardiomyopathy, Left ventricle non-compaction, Left ventricular function

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Article Information

Correspondence

Enrico Vizzardi, MD, Section of Cardiovascular Disease, Department of Applied Experimental Medicine, University of Brescia, Via Valsabbina, 19, 25123 Brescia – Italy, vizzardi@unibs.it

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