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Hypertension is the leading modifiable risk factor for global cardiovascular disease, responsible for an estimated 10.8 million deaths and more than 200 million disability-adjusted life years annually.1 Despite the availability of effective pharmacological and lifestyle interventions, prevalence continues to rise, particularly in low- and middle-income countries (LMICs), where over three-quarters of all cases now occur.2 The condition’s […]

Are there differences in acute phase inflammation markers regarding the type of heart failure?

Ignacio J. Sánchez-Lázaro, Luis Almenar-Bonet, Edelmiro Reganon-Salvador, Virtudes Vila-Liante, Vicenta Martínez-Sales, Luis Martínez-Dolz, Jaime Agüero-Ramón-Llin, Antonio Salvador-Sanz
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Published Online: Aug 7th 2018 Heart International 2011;6(2):e17 DOI: https://doi.org/10.4081/hi.2011.e17
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Abstract

Overview

This study aimed to determine if there are
differences in inflammatory markers in the
acute phase between systolic heart failure and
heart failure with preserved systolic function.
One hundred and thirty-one patients with
acute heart failure were recruited consecutively.
At admission, plasma fibrinogen, Creactive
protein, sialic acid, von Willebrand
factor, vascular endothelial growth factor,
interleukin-6 and NTproBNP were all evaluated.
If the ejection fraction was 45% or over
patients were included in the HF-PSF group;
the remaining patients were included in the
SHF group. The HF-PSF patients were older
(72±10 vs 63±12 years, P<0.001), presented a higher rate of atrial fibrillation (56.1 vs 21.3%, P<0.001), and had a lower rate of hemoglobin (12.2±2 vs 13.3±2.1 g/dL, P<0.01). No significant differences were observed in the inflammation markers analyzed among SHF and HFPSF groups. In the acute phase of heart failure there is a marked elevation of inflammatory markers but there are no differences in the inflammatory markers analyzed between the two different types of heart failure.

Keywords

Heart failure, inflammation

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Article Information

Correspondence

Ignacio J. Sánchez-Lázaro, Avda. Ausias March 2, esc. 2, pta. 15, 46111, Rocafort, Valencia, Spain. Tel. +34.629821756 – Fax: +34.961973314. E-mail: ignaciosanchezlazaro@gmail.com

Received

2011-05-07T00:00:00

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